By allowing ads to appear on this site, you support the local businesses who, in turn, support great journalism.
UC Merced professor designs HIV inhibitor
Placeholder Image

University of California, Merced professor Patricia LiWang has designed what may be the most effective chemical inhibitor against human immunodeficiency virus infection, the university announced this week.

LiWang's discovery combines two existing drugs to work between several times and several hundred times more effectively than existing inhibitors, depending on the strain of HIV.

The new inhibitor blocks HIV from entering a cell at two different steps of viral entry, an approach among the forefront of new strategies to stop the virus. Other existing inhibitors look to stop HIV from replicating or from integrating in to the human genome, rather than preventing entry.

Like all HIV inhibitors, LiWang's creation faces the challenge of the frequently-mutating virus, which oftentimes rapidly adapts to resist new drugs.

“However, since this drug is a combination of two inhibitors, it would be nearly impossible for a virus to mutate so it wouldn't get hit with either one of these drugs," LiWang said.

The inhibitor uses a special protein produced by harmless bacteria, allowing for easy production. The inhibitor could be added to a vaginal cream to protect against the virus.

More testing and development is needed before the drug can be used, including testing for side effects. Clinical trials are years away.

Stanislaus State ranked among nation’s best colleges
CSUS
Stanislaus State’s Academic Senate voted in favor of a bill that would require students enrolled in all 23 California State University campuses to take one 3-credit unit of any qualifying Ethnic Studies course before they graduate (Journal file photo).
The Princeton Review has named Stanislaus State one of the nation’s Best Value Colleges for 2025, recognizing the University for offering one of the highest returns on investment (ROI) in higher education.
Would you like to keep reading?
You have 1 free view remaining. Use your last view to read more.